Silicon-Based Life?

One favorite of science fiction writers is life based on the chemistry of silicon rather than carbon, because silicon is probably the element most similar in chemical properties to carbon. However, even though silicon is the most similar, it is not very similar; carbon chemistry is still much richer than that of silicon. And we have the observation that even though silicon is more than a hundred times more abundant than carbon, we know of no silicon-based life forms walking around on our planet.