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Until the time of Einstein, mass and energy were considered to be two separate things. In the special theory of relativity, Einstein demonstrated that neither mass nor energy were conserved separately, but that they could be traded one for the other and only the total "mass-energy" was conserved. The relationship between the mass and the energy is contained in what is probably the most famous equation in science,
E = mc2
where m is the mass, c is the speed of light, and E is the energy equivalent of the mass.